Iodoral has helped relief many of the syptoms of Hypothyoidism. Although I still have chronic fatigue, iodine has lessen the fatigue to where I am able to excercise and begin to enjoy being active again. The tingling/burning in my fingers and toes (from cold) are nil and my menstrual cycle has almost returned to normal. The cold weather is more bareable than it use to be (I was extremely cold all the time). Iodoral has also helped with the Reynaud's syndrome.